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Pauling was first introduced to the idea of excessive-dose vitamin C by biochemist Irwin Stone in 1966 and commenced taking a number of grams day by day to prevent colds. Excited by the results, he researched the medical literature and revealed “Vitamin C and the Frequent Cold” in 1970. He started an extended clinical collaboration with the British cancer surgeon, Ewan Cameron , MD 1 in 1971 on the usage of intravenous and oral vitamin C as most cancers therapy for terminal patients. Cameron and Pauling wrote many technical papers and a well-liked guide, “Most cancers and Vitamin C”, that discussed their observations. He later collaborated with the Canadian doctor, Abram Hoffer , MD, PhD, 2 on a micronutrient regimen, together with high-dose vitamin C, as adjunctive most cancers remedy.